BioPhotonics Lab

Moscow, Russia

About Us

Mission:

To develop new approaches combining visualization, diagnostics, and therapy (theranostics) using the synergy of last achievements of photonics, acoustics and material science for biomedical applications, and to bridge a gap between biophotonic research and clinical applications together with academic and industrial partners

Technologies under development:

Special fiber (photon crystal fibers, microstructured waveguides), photonic integrated circuits (PIC), optoacoustics, THz, quantum sensors, acoustics (focused ultrasound, sonoluminescence, tweezers), nanostructured materials (contrast agent, sensors, drug delivery carriers), microfluidics, surface modification – synergy in combination

Applications (Market):

Theranostics including imaging & sensing and light-, photodynamic-,sonodynamic therapy, surgical & diagnostic endoscopy, point-of-care diagnostics and health tracker (including data processing with artificial intelligence), robotic surgery​

Tasks:

  • visualization of pathology tissue and interface of normal/pathological tissues diagnostics using of modern photonics (optical fibers, PIC, optoacoustics (OA), THz, quantum sensors), acoustics, and materials science (microfluidics, surface modification, multimodal contrast agents based on nanostructured particles (US-, OA-, Fluorescent and Magnetic Resonance Imaging));

  • R&D of devices combining photonic tools (optical fibers, PIC, optoacoustics, THz) for detection of biologically important markers and drug delivery targeted systems with remote controlled by acoustic and electromagnetic fields;

  • R&D of new methods and devices for diagnostics of pathology state and transient processes from normal state to pathology and its correction on cell, tissue, and body levels (exosome detection, circulation tumor cell detection, oxygenation monitoring, etc.) using modern photonics (optical fibers, PIC, optoacoustics, THz, quantum sensors) and acoustics (focused ultrasound (US), sonoluminescence).

Spin-off company "TetraQuant"

TetraQuant is a Skolkovo startup company founded in 2019 by scientists and engineers from BioPhotonics Group, Skolkovo Institute of Science and Technology with interdisciplinary background to produce tools and equipment that they have relied on routinely and now aim to help other s cientists to make their laboratory tasks easier and with great reproducibility of results.

Opportunities for students

  • Long Term Academic Mobility: Skoltech offers Academic Mobility program, which allows students to spend up to 4 months in an international institution to conduct MSc Thesis research. A lot of students in our lab participated in this program and successfully conducted their research in top-rated universities in Europe and the USA. This resulted in multiple collaborative projects and publications.
  • Short Term Academic Mobility: Skoltech encourages students to attend Russian and International conferences and present their results. All of the expences can be reimbursed!
  • Infrostructure: students have access to modern equipment.
  • The Team: work in a friendly environment with a great multisidisciplinary team!

News

Best Project Excellence Award

12.10.2022

The summer industrial immersion project "Development of immunomagnetic particles based on nano- and submicron particles for specific isolation of biomarkers" of our MSc students Olga Griaznova and Nikita Grishaev, that was cunducted in TetraQuant, has been chosen by the PQM Program as the best one.



Russian Presidential Scholarship to Study Abroad

31.08.2022

Three PhD students from our lab received the Russian Presidential Scholarship to Study Abroad!
The scholarship covers teaching, visa processing, tickets, accommodation, medical insurance and even local transportation during their internships. Sergei Perkov, Maxim Mokrousov, and Alexey Kuzin will study at the Bar Ilan University, Tel Aviv University and Fudan University.



Master's thesis defence

17.06.2022

Liza Maksimova has successfully defended her Master's thesis entitled "Contrast agents based on microbubbles stabilized by albumin and decorated with nanoparticles and organic dyes for multimodal imaging"






People

Fellow Workers

Dmitry Gorin
Head of Lab, Professor
Alexey Yashchenok
Leading Research Scientist, DSc
Sergei German
Research Scientist, PhD
Institute of Spectroscopy RAS
Marina Novoselova
Research Scientist, PhD
Maxim Kurochkin
Research Scientist, PhD
Polina Rudakovskaya
Research Scientist, PhD
Anatolii Abalymov
Research Scientist, PhD

PhD Students

Maksim Mokrousov
PhD-4 student
Anastasiia Merdalimova
PhD-4 student
Julijana Cvjetinovic
PhD-4 student
Sergei Perkov
PhD-3 student
Stas Perevoschikov
PhD-3 student
Igor Sergeev
PhD-2 student
Alexey Kuzin
PhD-2 student
Tatiana Estifeeva
PhD-1 student
Ekaterina Moiseeva
PhD-1 student
Dmitrii Tsiurko
PhD-1 student

Master Students

Viktor Vorobev
MSc-2 student
Olga Griaznova
MSc-2 student
Nikita Grishaev
MSc-2 student
Krupamay Panda
MSc-2 student
Altynai Sydygalieva
MSc-1 student

Volunteers

Maria Blindman
Specialist-5 student, Sechenov University
Pavel Kuzmin
BSc-3 student,
Mendeleev University
Oleg Maslov
BSc-3 student,
Mendeleev University
Daria Terentieva
BSc-4 student,
Mendeleev University

Alumni



Conferences



Recently published articles:

  1. Aleksei Kuzin, Vasiliy Chernyshev, Vadim Kovalyuk, Pavel An, Alexander Golikov, Gregory Goltsman, and Dmitry Gorin, In Situ Monitoring of Layer-by-Layer Assembly Surface Modification of Nanophotonic-Microfluidic Sensor, Analytical Chemistry, 2022, DOI: 10.1021/acs.analchem.2c03909

  2. A. M. Yashchenok, V. S. Chernyshev, E. V. Konovalova, R. Kholodenko, E. Tsydenzhapova, V. O. Shipunova, A. A. Schulga, S. M. Deyev, D. A. Gorin, Anti-CD63-Oligonucleotide Functionalized Magnetic Beads for the Rapid Isolation of Small Extracellular Vesicles and Detection of EpCAM and HER2 Membrane Receptors using DARPin Probes, Anal. Sens., 2022, e202200059, https://doi.org/10.1002/anse.202200059

  3. Rudakovskaya, P.G., Barmin, R.A., Kuzmin, P.S., Fedotkina, E.P., Sencha, A.N., Gorin, D.A, Microbubbles Stabilized by Protein Shell: From Pioneering Ultrasound Contrast Agents to Advanced Theranostic Systems, Pharmaceutics, 2022, 14, 1236. https://doi.org/10.3390/pharmaceutics14061236

  4. Roman A. Barmin, Elizaveta A. Maksimova, Polina G. Rudakovskaya, Alexey V. Gayer, Evgeny A. Shirshin, Kirill S. Petrov, Daria A. Terentyeva, Olga I. Gusliakova, Olga A. Sindeeva, Oleg A. Klimenko, Roman N. Chuprov-Netochin, Alexander A. Solovev, Gaoshan Huang, Anastasia V. Ryabova, Victor B. Loschenov, Dmitry A. Gorin, Albumin microbubbles conjugated with zinc and aluminum phthalocyanine dyes for enhanced photodynamic activity, Colloids and Surfaces B: Biointerfaces, 2022, 219. https://doi.org/10.1016/j.colsurfb.2022.112856

  5. Tatiana O. Abakumova, Olga I. Gusliakova, Julijana Cvjetinovic, Olga I. Efimova, Elena V. Konovalova, Alexey A. Schulga, Timofei S. Zatsepin, Dmitry A. Gorin, Alexey M. Yashchenok, and Sergey M. Deyev, Barnase-Loaded Vaterite Nanoparticles Functionalized by EpCAM Targeting Vectors for the Treatment of Lung Diseases, ACS Applied Nano Materials, 2022, 5, 10744-10754, https://pubs.acs.org/doi/10.1021/acsanm.2c02078

  6. Roman A.Barmin, Polina G.Rudakovskaya, Vasiliy S.Chernyshev, Olga I.Guslyakova, Olga A.Sindeeva, Ekaterina S.Prikhozhdenko, Daniil N.Bratashov, Arkady S.Abdurashitov, Elizaveta A.Maksimova, Polina A.Demina, Evgeny V.Khaydukov, Alexey V.Gayer, Evgeny A.Shirshin, Alexander A.Solovev, Yongfeng Mei, Dmitry A.Gorin, Impact of fluorescent dyes on the physicochemical parameters of microbubbles stabilized by albumin-dye complex, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022, 647. https://doi.org/10.1016/j.colsurfa.2022.129095



Projects

  1. Optical methods for monitoring the growth of the diatom algae and their activity in the carbon dioxide capturing
    Project Team: Dmitry Gorin, Alexander Korsunsky, Yekaterina Bedoshvili, Nickolai Davidovich, Sergey German, Julijana Cvjetinovic, Sergei Perkov, Yulia Zakharova, Elvira Bairamova

  2. Noninvasive optical sensing for personalized treatment of hemangioma
    Project Team: Dmitry Gorin, Sergei Pekov, Viktor Vorobev, Sergey German, Sergey Gorodkov

  3. New functional agents of hybrid imaging based on amphiphilic polymers for the tasks of reproductive medicine
    Project Team: Polina Rudakovskaya, Roman Barmin, Liza Maksimova, Roman Chuprov-Netochin

  4. Comprehensive physical-chemical method for localizing of therapeutic agents within the target lymph node using magnetic control systems and submicron carriers
    Project Team: Maxim Kurochkin

  5. Development of multimodal contrast agents for diagnostics of sentinel lymph nodes
    Project Team: Novoselova M.N., German S.V., Kurochkin M.A., Efimova O. and others.

  6. Investigation of the effect of membrane macromolecules of extracellular nanovesicles on their surface activity and adsorption to interfaces
    Project Team: Vasiliy Chernyshev

  7. Photoacoustic technologies for early theranostics of metastatic tumors
    Project Team: Dmitry Gorin, A.Yashchenok, M. Novoselova, S. German, M. Mokrousov, D.Nozdriukhin



Equipment

Laser Analyzer Zetasizer Nano ZS
Flow Cytometry System CytoFLEX B5-R3-V5
Operetta High Content Imaging System
IVIS Spectrum CT In Vivo Imaging System
Optoacoustic microscopy RSOM Explorer P50

Partners

Industrial Partners

Academic Partners

Contacts

Address

Rooms 120, 103.1, 044
Skolkovo Institute of Science and Technology,
Skolkovo Innovation Center, Nobel st, Building 3,
Moscow 121205,
Russia

How to find us?

On a subway train: reach "Skolkovo" station of Moscow Central Diameter D1, then take bus Sk1 to "Tatneft".
On a bus: from "Slavyanskiy bulvar" subway station take Sk express (bus), then change at "Technopark" station to minibus №3 or minibus №5.

Head of Lab

Prof. Dmitry Gorin
D.Gorin@skoltech.ru

Website administrator

Sergei Perkov
sergey.perkov97@gmail.com