BioPhotonics Group

Moscow, Russia

About Us

Mission:

To develop new approaches combining visualization, diagnostics, and therapy (theranostics) using the synergy of last achievements of photonics, acoustics and material science for biomedical applications, and to bridge a gap between biophotonic research and clinical applications together with academic and industrial partners

Technologies under development:

Special fiber (photon crystal fibers, microstructured waveguides), photonic integrated circuits (PIC), optoacoustics, THz, quantum sensors, acoustics (focused ultrasound, sonoluminescence, tweezers), nanostructured materials (contrast agent, sensors, drug delivery carriers), microfluidics, surface modification – synergy in combination

Applications (Market):

Theranostics including imaging & sensing and light-, photodynamic-,sonodynamic therapy, surgical & diagnostic endoscopy, point-of-care diagnostics and health tracker (including data processing with artificial intelligence), robotic surgery​

Tasks:

  • visualization of pathology tissue and interface of normal/pathological tissues diagnostics using of modern photonics (optical fibers, PIC, optoacoustics (OA), THz, quantum sensors), acoustics, and materials science (microfluidics, surface modification, multimodal contrast agents based on nanostructured particles (US-, OA-, Fluorescent and Magnetic Resonance Imaging));

  • R&D of devices combining photonic tools (optical fibers, PIC, optoacoustics, THz) for detection of biologically important markers and drug delivery targeted systems with remote controlled by acoustic and electromagnetic fields;

  • R&D of new methods and devices for diagnostics of pathology state and transient processes from normal state to pathology and its correction on cell, tissue, and body levels (exosome detection, circulation tumor cell detection, oxygenation monitoring, etc.) using modern photonics (optical fibers, PIC, optoacoustics, THz, quantum sensors) and acoustics (focused ultrasound (US), sonoluminescence).

Spin-off company "TetraQuant"

TetraQuant is a Skolkovo startup company founded in 2019 by scientists and engineers from BioPhotonics Group, Skolkovo Institute of Science and Technology with interdisciplinary background to produce tools and equipment that they have relied on routinely and now aim to help other s cientists to make their laboratory tasks easier and with great reproducibility of results.

Opportunities for students

  • Long Term Academic Mobility: Skoltech offers Academic Mobility program, which allows students to spend up to 4 months in an international institution to conduct MSc Thesis research. A lot of students in our lab participated in this program and successfully conducted their research in top-rated universities in Europe and the USA. This resulted in multiple collaborative projects and publications.
  • Short Term Academic Mobility: Skoltech encourages students to attend Russian and International conferences and present their results. All of the expences can be reimbursed!
  • Infrostructure: students have access to modern equipment.
  • The Team: work in a friendly environment with a great multisidisciplinary team!

News

Laboratory Seminar

14.10.2021

Weekly laboratory seminar was organized. Our new master's students Olga Griaznova and Nikita Grishaev talked about their scientific background and research plans in the laboratory.



Laboratory Seminars Renewal

07.10.2021

The first offline laboratory seminar was organized since the start of the pandemic! Our new master's students Kirill Malakhov, Viktor Vorobev, were the first to take the floor and present their scientific background and research plans in the laboratory.



Master's theses defences

17.06.2021

Roman Barmin and Igor Sergeev have successfully defended their Master's theses.
Roman's thesis entitled "Contrast agents based on gas bubbles for photoacoustic and ultrasound-driven applications" and Igor's thesis entitled "Influence of photodynamic effect with the presence of inorganic nanoparticles on cell viability" both were graded as "A".




People

Fellow workers

Dmitry Gorin
Head of Group, Professor
Alexey Yashchenok
Leading Research Scientist, DSc
Sergei German
Research Scientist, PhD
Institute of Spectroscopy RAS
Marina Novoselova
Research Scientist, PhD
Vasiliy Chernyshev
Research Scientist, PhD
Maxim Kurochkin
Research Scientist, PhD
Polina Rudakovskaya
Research Scientist, PhD

PhD Students

Timur Ermatov
PhD-4 student
Maksim Mokrousov
PhD-2 student
Anastasiia Merdalimova
PhD-2 student
Julijana Cvjetinovic
PhD-2 student
Sergei Perkov
PhD-1 student
Stas Perevoschikov
PhD-1 student

Master Students

Liza Maksimova
MSc-2 student
Kirill Malakhov
MSc-1 student
Viktor Vorobev
MSc-1 student
Olga Griaznova
MSc-1 student
Nikita Grishaev
MSc-1 student

Volunteers

Igor Sergeev
MSc
Maria Blindman
BSc-4 student, Sechenov University

Alumni



Recently published articles:

  1. E.A. Maksimova , R.A. Barmin, P.G. Rudakovskaya, O.A. Sindeeva, E.S. Prikhozhdenko; A.M. Yashchenok, B.N. Khlebtsov, A.A. Solovev, G. Huang, Y. Mei, Kanti Dey, D.A. Gorin Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging. Micromachines 2021, 12, 1161. https://doi.org/10.3390/mi12101161

  2. Timur Ermatov, Ivan Gnusov, Julia Skibina, Roman E. Noskov, and Dmitry Gorin, Noncontact characterization of microstructured optical fibers coating in real time, Opt. Lett. 46, 4793-4796 (2021), https://doi.org/10.1364/OL.433208

  3. Timur Ermatov, Marina Novoselova, Julia Skibina, Andrey Machnev, Dmitry Gorin, and Roman E. Noskov, Ultrasmooth, biocompatible, and removable nanocoating for hollow-core microstructured optical fibers, Opt. Lett. 46, 4828-4831 (2021)б https://doi.org/10.1364/OL.436220

  4. R. E. Noskov, A. Machnev, I.I. Shishkin, M. V. Novoselova, A.V. Gayer, A. A. Ezhov, E. A. Shirshin, S. V. German, I.D. Rukhlenko, S. Fleming, B. N. Khlebtsov, D. A. Gorin, P. Ginzburg, Golden Vaterite as a Mesoscopic Metamaterial for Biophotonic Applications, Advanced Materials 2021, 2008484, https://doi.org/10.1002/adma.202008484, (IF=27.398, Q1, Nature Indexing Journal)

  5. M.D. Mokrousov, W. Thompson, S.A. Ermilov, T. Abakumova, M.V. Novoselova, O. A. Inozemtseva, T. S. Zatsepin, V. P. Zharov, E.I. Galanzha, D. A. Gorin, (2021). Indocyanine green dye based bimodal contrast agent tested by photoacoustic/fluorescence tomography setup. Biomedical Optics Express, 12(6), 3181-3195, https://doi.org/10.1364/BOE.419461 (IF=3.921, Q1)

  6. J. Mujtaba, J. Liu, K. K. Dey, T. Li, R. Chakraborty, K. Xu, D. Makarov, R.A. Barmin, D.A. Gorin, V. Tolstoy, G. S. Huang, A. A. Solovev and Y. F. Mei. Micro-Bio-Chemo-Mechanical-Systems: Micromotors, Nanozymes, and Microfluidics for Biomedical Applications. Advanced Materials, 2021, 2007456(1-40), (2021), doi.org/10.1002/adma.202007465, (IF=27.398, Q1, Nature Indexing Journal)



Projects

  1. New functional agents of hybrid imaging based on amphiphilic polymers for the tasks of reproductive medicine
    Project Team: Polina Rudakovskaya, Roman Barmin, Liza Maksimova, Roman Chuprov-Netochin

  2. The development of a device for hematomas and inflammations phototherapy
    Project Team: Sergei Perkov, Kirill Malakhov

  3. The development of multifunctional particles for targeted stimuli-responsive therapy and diagnostics of prostate cancer
    Project Team: Gorin D., Novoselova M.V., German S.V., Perevoschikov S.V. and others

  4. Bioactive ultrasound-driven microbubbles for theranostics
    Project Team: Gorin D., Yashchenok A.M., Novoselova M.V., German S.V., Rudakovskaya P.G., Gusliakova O.I. and others

  5. Microstructured optical waveguides for the concentrations and refractive index measurements of the proteins
    Project Team: Timur Ermatov

  6. Comprehensive physical-chemical method for localizing of therapeutic agents within the target lymph node using magnetic control systems and submicron carriers
    Project Team: Maxim Kurochkin

  7. Investigation of the effect of membrane macromolecules of extracellular nanovesicles on their surface activity and adsorption to interfaces
    Project Team: Vasiliy Chernyshev

  8. A new approach for the treatment of viral infections of the respiratory tract, including SARS-CoV-2, based on targeted delivery of vaterite particles with encapsulated ribonuclease
    Project Team: Alexey Yashchenok, Abakumova T.O., Rudakovskaya P.G., Konovalova E.V. and others.

  9. Photoacoustic technologies for early theranostics of metastatic tumors
    Project Team: Dmitry Gorin, A.Yashchenok, M. Novoselova, S. German, M. Mokrousov, D.Nozdriukhin



Equipment

Laser Analyzer Zetasizer Nano ZS
Flow Cytometry System CytoFLEX B5-R3-V5
Operetta High Content Imaging System
IVIS Spectrum CT In Vivo Imaging System
Optoacoustic microscopy RSOM Explorer P50

Partners

Industrial Partners

Academic Partners

Contacts

Address

Rooms 111, 044
Skolkovo Institute of Science and Technology,
Skolkovo Innovation Center, Nobel st, Building 3,
Moscow 121205,
Russia

How to find us?

On a subway train: reach "Skolkovo" station of Moscow Central Diameter D1, then take minibus №1.
On a bus: from "Slavyanskiy bulvar" subway station take Sk express (bus), then change at "Technopark" station to minibus №3 or minibus №5.

Head of Lab

Prof. Dmitry Gorin
D.Gorin@skoltech.ru

Website administrator

Sergei Perkov
sergey.perkov97@gmail.com